MicroRNAs in Liver Disease: Bench to Bedside

MicroRNAs in Liver Disease: Bench to Bedside.

MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by pairing with partially complementary target sequences in the 3'UTRs of mRNAs to promote degradation and/or block translation. Aberrant miR expression is associated with development of multiple diseases including hepatic diseases. The role of miRs in the regulation of gene expression and rapid progress in the ...

Ultrasonic Imaging in Liver Disease: From Bench to Bedside

Hepatology is an excellent example of how results deriving from basic science influence our everyday clinical practice. This involves diagnostic procedures as well as therapeutic developments. The role of diagnostic imaging in the assessment of liver disease continues to gain in importance. Imaging of the liver has progressed rapidly during the past decade with continued advancement of current ...

Liver fibrosis -- from bench to bedside.

Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of great bedside relevance to practicing hepatologists. This evolution reflects growing awareness notonlyof themolecularunderpinningsoffibrosis, but also of its natural history and methods of detection in chronic liver disease. These advances have culminated in clear evidence that cirrhosis can be rever...

Inflammatory Bowel Disease: From Bench to Bedside

From bench to bedside

Because the microcirculation has emerged as an important reanimation target, appropriate methods to monitor the microcirculatory function are crucial. Several teams have now succeeded in crossing this bridge from bench to bedside, but the choice of the tissues of interest remains a debate. The potential accessible vascular beds that doctors could use in reanimation strategies and the relationsh...